历史人物

科学人物

姓名：胡松年 性别：男 出生年月：1969年1月21日 出生地：天津市 简历 学习经历： 1991年9月-1996年7月中国农业大学 生物化学专业 获理学博士学位 1987年9月-1991年7月天津商学院 食品工程专业 获理学学士学位 科研工作经历： 2003年2月-至今 中国科学院北京基因组研究所 研究员 博士生导师 2002年2月-2008年9月 浙江大学沃森基因组科学研究院教授 硕士生导师 1999年8月-2003年2月 中国科学院遗传与发育研究所人类基因组中心总工程师 1998年8月–1999年7月 美国西雅图华盛顿大学基因组中心访问学者 1996年9月–1998年7月 中国医学科学院基础医学研究所助理研究员 学术任职： 2011年至今 Nature Reviews Genetics (Chinese Edition) 编委 2010年至今 Frontiers in Plant Genetics and Genomics 编委 2008年至今 BMC Research Notes 编委 2007年至今 遗传 编委 获奖情况： 2008年 中国科学院朱李月华优秀教师奖 2007年 利用EST信息资源大规模克隆家蚕功能基因 浙江省科学技术一等奖 2006年 中国科学院优秀教师奖 2003年 中国杂交水稻基因组计划 中国科学院杰出科技成就集体奖 2002年 中国杂交水稻基因组计划 香港求是科技基金求是杰出科技成就集体奖 主持和承担的科研项目： 项目资助 类别 项目名称(批准号) 起止年份 资助金额（万元） 本人在项目中的作用 进展 国家自然 科学基金 1%人类基因组计划“完成图”的绘制（30199010） 2000.6-2001.6 500 项目成员 （第3位） 已完成 中科院 知识创新 1%人类基因组和中国重要战略资源生物基因组计划（KSCX1-01） 2000.6-2001.12 2500 项目成员 （第5位） 已完成 北京市科委 大规模基因组测序技术平台的建立与优化 2000.10-2001.10 100 项目负责人 已完成 科技部 863计划 超级杂交水稻（籼稻） 基因组测序（2001AA225041） 2001.1-2002.12 1500 项目成员 （第2位） 已完成 科技部 863计划 水稻基因组精细图的绘制（2002AA229021） 2002.1-2003.12 1500 项目成员 （第9位） 已完成 科技部 家猪基因组计划（2002AA229061） 2002.1-2004.12 80 项目成员 （第2位） 已完成 国家自然 科学基金 人类基因组的研究策略和应用（30221004） 2003.1-2005.12 720 项目成员 （第6位） 已完成 中科院 知识创新 家蚕基因组框架图和家鸡基因组多态性图谱的绘制（KSCX1-SW-25） 2003.7-2005.6 3500 项目成员 （第9位） 已完成 国家自然 科学基金 常染色体显性先天性静止性夜盲症致病基因的筛查与致病机理研究（30470962） 2005.1-2007.12 18 项目负责人 已完成 科技部 973计划 转录组纵深信息挖掘(“以细胞为单元的人类基因转录组与蛋白质组的关联性研究”项目下属课题)（2006CB910403） 2006.11-2010.8 329 课题负责人 已完成 国家自然 科学基金 水稻中细胞器到细胞核以及细胞器间的DNA序列迁移及其在基因组进化，细胞器起源和进化中的研究（30600111） 2007.2-2009.12 22 项目成员 （第2位） 已完成 中科院 知识创新 非编码RNA的鉴定、功能研究以及算法软件的开发（KSCX2-EW-R-01-04） 2011.1-2013.12 140 子课题 负责人 进行中 主要学术成绩 1、 人类基因组计划及后续研究 2、水稻基因组计划及后续研究 3、以第二代测序为基础的哺乳动物转录组学研究 4、小鼠基因组表观修饰与基因表达的研究 拟开展研究方向 1．第二代测序数据产出和数据管理平台构建 2．非编码RNA的注释 3．小鼠基因表达和表观调控的网络研究 近五年内发表的5篇代表性论著 1.　 Cui, P., L. Zhang, Q. Lin, F. Ding, C. Xin, X. Fang, S. Hu, and J. Yu, A novel mechanism of epigenetic regulation: nucleosome-space occupancy. Biochemical and Biophysical Research Communications, 2010. 391(1): p. 884-889. （并列通讯作者） 2.　 Cui, P., Q. Lin, C. Xin, L. Han, L. An, Y. Wang, Z. Hu, F. Ding, L. Zhang, S. Hu, H. Hang, and J. Yu, Hydroxyurea-induced global transcriptional suppression in mouse ES cells. Carcinogenesis, 2010. 31(9): p. 1661-1668. （并列通讯作者） 3.　 Cui, P., Q. Lin, F. Ding, C. Xin, W. Gong, L. Zhang, J. Geng, B. Zhang, X. Yu, J. Yang, S. Hu, and J. Yu, A comparison between ribo-minus RNA-sequencing and polyA-selected RNA-sequencing. Genomics, 2010. 96(5): p. 259-265. （并列通讯作者） 4.　 Mu, Y., F. Ding, P. Cui, J. Ao, S. Hu, and X. Chen, Transcriptome and expression profiling analysis revealed changes of multiple signaling pathways involved in immunity in the large yellow croaker during Aeromonas hydrophila infection. BMC Genomics, 2010. 11(1): p. 506. （并列通讯作者） 5.　 Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM: Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. The Pharmacogenomics Journal 2009. (并列通讯作者) 近五年内发表的全部论著 6.　 Zhu, J., F. He, D. Wang, K. Liu, D. Huang, J. Xiao, J. Wu, S. Hu, and J. Yu, A novel role for minimal introns: routing mRNAs to the cytosol. PLoS One, 2010. 5(4): p. e10144. 7.　 Zhang, Y., F. Zhang, H. Lin, L. Shi, P. Wang, Q. Gong, X. Li, M. Wang, S. Hu, J. Chu, and D.-M. Wang, Nucleotide polymorphism of the TNF gene cluster in six Chinese populations. Journal of Human Genetics, 2010. 55(6): p. 350-357. 8.　 Zhang, W., D. Yu, Z. Sun, R. Wu, X. Chen, W. Chen, H. Meng, S. Hu, and H. Zhang, Complete genome sequence of Lactobacillus casei Zhang, a new probiotic strain isolated from traditional home-made koumiss in Inner Mongolia of China. Journal of Bacteriology, 2010. 192(19): p. 5268-5269. 9.　 Zhang, W., D. Yu, Z. Sun, W. Chen, S. Hu, H. Meng, and H. Zhang, The comparative analysis of a prophage remnant Lcazh1 in relation to other Lactobacillus prophages, particularly Lp3. International Journal of Dairy Technology, 2010. 63(3): p. 413-417. 10.　 Zhang, G., M. Su, D. Wang, S. Hu, M. Liu, J. Li, H. Lin, F. Zhang, D. Tian, H. Yang, Z. Liu, S. Lian, Q. Guo, X. Li, and Y. Gao, Genetic heterogeneity of oesophageal cancer in high-incidence areas of southern and northern china. PLoS One, 2010. 5(3): p. e9668. 11.　 Zhang, G., W. Chu, S. Hu, T. Meng, L. Pan, R. Zhou, Z. Liu, and J. Zhang, Identification and analysis of muscle-related protein isoforms expressed in the white muscle of the mandarin fish (Siniperca chuatsi). Marine Biotechnology (New York, N.Y.), 2010.（并列通讯作者） 12.　 Zhang, C., D. Zhou, S. Zheng, L. Liu, S. Tao, L. Yang, S. Hu, and Q. Feng, A chymotrypsin-like serine protease cDNA involved in food protein digestion in the common cutworm, Spodoptera litura: Cloning, characterization, developmental and induced expression patterns, and localization. Journal of insect physiology, 2010. 56(7): p. 788-799. 13.　 Ye, J., L.-H. Su, C.-L. Chen, S. Hu, J. Wang, J. Yu, and C.-H. Chiu, Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67. Plasmid, 2010. 14.　 Yang, Y., W. Gong, W. Wang, X. Yu, S. Hu, and J. Yu, The alterations of energy metabolism-related protein patterns in brown adipose tissue of rats during cold-induced thermogenesis. Progress in Biochemistry and Biophysics, 2010. 37(10): p. 1108-1119. 15.　 Wu, Q., J. Song, Y. Sun, F. Suo, C. Li, H. Luo, Y. Liu, Y. Li, X. Zhang, H. Yao, X. Li, S. Hu, and C. Sun, Transcript profiles of Panax quinquefolius from flower, leaf and root bring new insights into genes related to ginsenosides biosynthesis and transcriptional regulation. Physiologia Plantarum, 2010. 138(2): p. 134-149. 16.　 Wang, L., L. Jiang, S. Hu, and Y. Wang, Characterization of evolutionarily conserved microRNAs in amphioxus. Genomics, Proteomics & Bioinformatics, 2010. 8(1): p. 10-21. （并列通讯作者） 17.　 Qu, H., H. Wu, T. Zhang, Z. Zhang, S. Hu, and J. Yu, Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes. Research in Microbiology, 2010. 161(10): p. 838-846. 18.　 Niu, J., H. Hu, S. Hu, G. Wang, G. Peng, and S. Sun, Analysis of expressed sequence tags from the Ulva prolifera (Chlorophyta) Chinese Journal of Oceanology and Limnology, 2010. 28(1): p. 26-36. （并列通讯作者） 19.　 Mu, Y., F. Ding, P. Cui, J. Ao, S. Hu, and X. Chen, Transcriptome and expression profiling analysis revealed changes of multiple signaling pathways involved in immunity in the large yellow croaker during Aeromonas hydrophila infection. BMC Genomics, 2010. 11(1): p. 506. （并列通讯作者） 20.　 Liu, W., D. Huang, K. Liu,S. Hu, J. Yu, G. Gao, and S. Song, Discovery, identification and comparative analysis of non-specific lipid transfer protein (nsLtp) family in Solanacese. Genomics, Proteomics & Bioinformatics, 2010. 8(4): p. 229-237. 21.　 Liu, F., D. Wang, J. Fu, G. Sun, Y. Shen, L. Dong, B. Zhang, S. Hu, and J. Li, Identification of immune-relevant genes by expressed sequence tag analysis of head kidney from grass carp (Ctenopharyngodon idella). Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2010. 5(2): p. 116-123. （并列通讯作者） 22.　 Lin, H., H. Fan, F. Zhang, X. Huang, K. Lin, L. Shi, S. Hu, J. Chu, and D.-M. Wang, Genetic relationships of ethnic minorities in Southwest China revealed by microsatellite markers. PLoS One, 2010. 5(3): p. e9895. 23.　 Li, K., J. Geng, J. Qu, Y. Zhang, and S. Hu, Effectiveness of 10 polymorphic microsatellite markers for parentage and pedigree analysis in plateau pika (Ochotona curzoniae). BMC Genetics, 2010. 11(1): p. 101. （并列通讯作者） 24.　 He, X., S. Tao, J. Jin, S. Hu, and J. Yu, The most redundant sequences in human CpG island library are derived from mitochondrial genome. Genomics Proteomics Bioinformatics, 2010. 8(2): p. 81-91. （并列通讯作者） 25.　 Hao, L., X. Ge, H. Wan, S. Hu, M.J. Lercher, Y. Jun, and W.-H. Chen, Human functional genetic studies are biased against the medically most relevant primate-specific genes. BMC Evolutionary Biology, 2010. 10: p. 316. 26.　 Guo, H., W. Wang, N. Yang, B. Guo, S. Zhang, R. Yang, Y. Yuan, J. Yu, S. Hu, Q. Sun, and J. Yun, DNA barcoding provides distinction between Radix Astragali and its adulterants. Science China Life Sciences 2010. 53(8): p. 992-9. 27.　 Geng, J., K. Li, Y. Zhang, and S. Hu, A modified enrichment method to construct microsatellite library from Plateau Pika genome (Ochotona curzoniae). Genomics, Proteomics & Bioinformatics, 2010. 8(1): p. 72-76. （并列通讯作者） 28.　 Feng, B., L. Dong, D. Niu, S. Meng, B. Zhang, D. Liu, S. Hu, and J. Li, Identification of immune genes of the agamaki clam (Sinonovacula constricta) by squencing and bioinformatic analysis of ESTs. Marine Biotechnology (New York, N.Y.), 2010. 12(3): p. 282-291. （并列通讯作者） 29.　 Deng, X., L. Gu, C. Liu, T. Lu, F. Lu, Z. Lu, P. Cui, Y. Pei, B. Wang, S. Hu, and X. Cao, Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America, 2010. 107(44): p. 19114-9. 30.　 Cui, P., L. Zhang, Q. Lin, F. Ding, C. Xin, X. Fang, S. Hu, and J. Yu, A novel mechanism of epigenetic regulation: nucleosome-space occupancy. Biochemical and Biophysical Research Communications, 2010. 391(1): p. 884-889. （并列通讯作者） 31.　 Cui, P., Q. Lin, C. Xin, L. Han, L. An, Y. Wang, Z. Hu, F. Ding, L. Zhang, S. Hu, H. Hang, and J. Yu, Hydroxyurea-induced global transcriptional suppression in mouse ES cells. Carcinogenesis, 2010. 31(9): p. 1661-1668. （并列通讯作者） 32.　 Cui, P., Q. Lin, F. Ding, C. Xin, W. Gong, L. Zhang, J. Geng, B. Zhang, X. Yu, J. Yang, S. Hu, and J. Yu, A comparison between ribo-minus RNA-sequencing and polyA-selected RNA-sequencing. Genomics, 2010. 96(5): p. 259-265. （并列通讯作者） 33.　 Chen, X., X. Yu, Y. Cai, H. Zheng, D. Yu, G. Liu, Q. Zhou, S. Hu, and F. Hu, Next-generation small RNA sequencing for microRNAs profiling in the honey bee Apis mellifera. Insect Molecular Biology, 2010. 19(6): p. 799-805. （并列通讯作者） 34.　 Chen, K., L. Wang, M. Yang, J. Liu, C. Xin, S. Hu, and J. Yu, Sequence signatures of nucleosome positioning in Caenorhabditis elegans. Genomics Proteomics Bioinformatics, 2010. 8(2): p. 92-102. 35.　 Cai, Y., X. Yu, Q. Zhou, C. Yu, H. Hu, J. Liu, J. Yang, H. Lin, B. Zhang, P. Cui, S. Hu, and J. Yu, Novel microRNAs in silkworm (Bombyx mori). Functional and Integrative Genomics, 2010. 10(3): p. 405-415. （并列通讯作者） 36.　 Zhu J, Sun Y, Zhao F-Q, Yu J, Craig R, Hu S: Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms. BMC Genomics 2009, 10:117. 37.　 Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM: Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. The Pharmacogenomics Journal 2009. (并列通讯作者) 38.　 Zhao D, Song S, Wang Q, Zhang X, Hu S, Chen L: Discovery of immune-related genes in Chinese mitten crab (Eriocheir sinensis) by expressed sequence tag analysis of haemocytes. Aquaculture 2009, 287(3-4):297-303. 39.　 Zhang WY, Yu DL, Sun ZH, Alrideng C, Hu SN, Meng H, Zhang HP: Preliminary analysis of glutathione S-transferase homolog from Lactobacillus casei Zhang. Annals of Microbiology 2009, 59(4):727-731. 40.　 Zhang G, Zhang L, Zhang M, Pan L, Wang F, Huang J, Li G, Yu J, Songnian H: Screening and assessing 11 Mycobacterium tuberculosis proteins as potential serodiagnostical markers for discriminating TB patients from BCG vaccinees. Genomics Proteomics & Bioinformatics 2009, 7(3):107-115. 41.　 Zhang F, Zhang B, Xiang H, Hu S: Comparative analysis of clustered regularly interspaced short palindromic repeats (CRISPRs) loci in the genomes of halophilic archaea. Acta Microbiologica Sinica 2009, 49(11):1445-1453. 42.　 Zhan X, Ke C-H, Hu H-Y, Hu S-N, Wang D-X, Chen F: Isolation and characterization of eleven microsatellite loci in small abalone, Haliotis diversicolor Reeve. Conservation Genetics 2009, 10(4):1185-1187. (并列通讯作者) 43.　 Yu X, Zhou Q, Cai Y, Luo Q, Lin H, Hu S, Yu J: A discovery of novel microRNAs in the silkworm (Bombyx mori) genome. Genomics 2009, 94(6):438-444. (并列通讯作者) 44.　 Xu X, Song S, Wang Q, Qin F, Liu K, Zhang X, Hu S, Zhao Y: Analysis and comparison of a set of expressed sequence tags of the parthenogenetic water flea Daphnia carinata. Molecular Genetics and Genomics 2009, 282(2):197-203. 45.　 Wu P, Qi D, Chen L, Zhang H, Zhang X, Qin J, Hu S: Gene discovery from an ovary cDNA library of oriental river prawn Macrobrachium nipponense by ESTs annotation. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2009, 4(2):111-120. (并列通讯作者) 46.　 Wang L, Hao L, Li X, Hu S, Ge S, Yu J: SNP deserts of Asian cultivated rice: genomic regions under domestication. Journal of Evolutionary Biology 2009, 22(4):751-761. 47.　 Wang D, Zhang S, He F, Zhu J, Hu S, Yu J: How do variable substitution rates influence Ka and Ks calculations? . Genomics, Proteomics & Bioinformatics 2009, 7(3):116-127. 48.　 Song S, Huang Y, Wang X, Wei G, Qu H, Wang W, Ge X, Hu S, Liu G, Liang Y et al: HRGD: a database for mining potential heterosis-related genes in plants. Plant Molecular Biology 2009, 69(3):255-260. 49.　 Liu WQ, Feng Y, Wang Y, Zou QH, Chen F, Guo JT, Peng YH, Jin Y, Li YG, Hu SN et al: Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi. PLoS One 2009, 4(2):e4510. 50.　 Lin WC, Li SC, Shin JW, Hu SN, Yu XM, Huang TY, Chen SC, Chen HC, Chen SJ, Huang PJ et al: Identification of microRNA in the protist Trichomonas vaginalis. Genomics 2009, 93(5):487-493. 51.　 Li X, Tan L, Zhu Z, Huang H, Liu Y, Hu S, Sun C: Patterns of nucleotide diversity in wild and cultivated rice Plant Systematics and Evolution 2009, 281(1-4):97-106. 52.　 Li X, Tan L, Wang L, Hu S, Sun C: Isolation and characterization of conserved non-coding sequences among rice (Oryza sativa L.) paralogous regions. Molecular Genetics and Genomics 2009, 281(1):11-18. 53.　 Li K-x, Geng J-n, Yang J, Zhang Y-m, Hu S-n: Isolation and characterization of 13 microsatellite loci in the plateau pika （Ochotona curzoniae）. Conservation Genetics 2009, 10:785-787. (并列通讯作者) 54.　 Kou Z, Hu S, Li T: Genome evolution of novel influenza A (H1N1) viruses in humans. Chinese Science Bulletin 2009, 54:2159-2163. 55.　 Jiang H, Yin Y, Zhang X, Hu S, Wang Q: Chasing relationships between nutrition and reproduction: A comparative transcriptome analysis of hepatopancreas and testis from Eriocheir sinensis Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2009, 4(3):227-234. 56.　 Jiang H, Cai YM, Chen LQ, Zhang XW, Hu SN, Wang Q: Functional annotation and analysis of expressed sequence tags from the hepatopancreas of mitten crab (Eriocheir sinensis). Marine Biotechnology (New York, NY) 2009, 11(3):317-326. 57.　 Ji R, Cui P, Ding F, Geng J, Gao H, Zhang H, Yu J, Hu S, Meng H: Monophyletic origin of domestic bactrian camel (Camelus bactrianus) and its evolutionary relationship with the extant wild camel (Camelus bactrianus ferus). Animal Genetics 2009, 40(4):377-382. (并列通讯作者) 58.　 Feng B, Dong L, Niu D, Meng S, Zhang B, Liu D, Hu S, Li J: Identification of immune genes of the agamaki clam (Sinonovacula constricta) by sequencing and bioinformatic analysis of ESTs. Marine Biotechnology (New York, NY) 2009. (并列通讯作者) 59.　 Ding F, Tang P, Hsu MH, Cui P, Hu S, Yu J, Chiu CH: Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14. BMC Genomics 2009, 10:158. 60.　 Cui P, Liu H, Lin Q, Ding F, Zhuo G, Hu S, Liu D, Yang W, Zhan K, Zhang A et al: A complete mitochondrial genome of wheat (Triticum aestivum cv. Chinese Yumai), and fast evolving mitochondrial genes in higher plants. Journal of Genetics 2009, 88(3):299-307. 61.　 Cong P, Luo Y, Bao W, Hu S: Genomic organization and promoter analysis of the Trichomonas vaginalis core histone gene families. Parasitology International 2009. 62.　 Chen Y, Zhu W, Sui S, Zhang X, Hu S: Sequence and evolutionary analysis of VP1 gene of ovine rotavirus NT. Acta Microbiologica Sinica 2009, 49(8):1055-1062. 63.　 Chen Y, Zhu W, Sui S, Yin Y, Hu S, Zhang X: Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses. Virus Genes 2009, 38(2):302-310. (并列通讯作者) 64.　 Chen WH, Ge X, Wang W, Yu J, Hu S: A gene catalogue for post-diapause development of an anhydrobiotic arthropod Artemia franciscana. BMC Genomics 2009, 10:52. 65.　 Chen H, Huang L, Hua X, Ying L, Hu Y, Wang C, Chen W, Yu X, Xu Z, Tian B, Hu S,Hua Y: Pleiotropic effects of RecQ in Deinococcus radiodurans. Genomics 2009, 94(5):333-340. (并列通讯作者) 66.　 Chai H, Yu DL, Zhang B, Fu Y, Hu SN: Analysis of expressed sequence tags in porcine uterus tissue. Biochemical Genetics 2009, 47(1-2):117-125. (并列通讯作者) 67.　 Cai Y, Yu X, Hu S, Yu J: A brief review on the mechanisms of miRNA regulation. Genomics, Proteomics & Bioinformatics 2009, 7(4):147-154. (并列通讯作者) 68.　 Bai Z, Yin Y, Hu S, Wang G, Zhang X, Li J: Identification of genes involved in immune response, microsatellite, and SNP markers from expressed sequence tags generated from hemocytes of freshwater pearl mussel (Hyriopsis cumingii). Marine Biotechnology (New York, NY) 2009, 11(4):520-530. 69.　 Zhu J, He F, Hu S, Yu J: On the nature of human housekeeping genes. Trends in Genetics 2008, 24(10):481-484. 70.　 Zhang Y, Chang B, Hu S, Wang D, Fang Q, Huang X, Zeng Q, Qi M: Single nucleotide polymorphisms and haplotype of four genes encoding cardiac ion channels in Chinese and their association with arrhythmia. Annals of Noninvasive Electrocardiology 2008, 13(2):180-190. 71.　 Zhang W, Yu D, Sun Z, Chen X, Bao Q, Meng H, Hu S, Zhang H: Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid 2008, 60(2):131-135. 72.　 Yu X, Zhou Q, Li SC, Luo Q, Cai Y, Lin WC, Chen H, Yang Y, Hu S, Yu J: The silkworm (Bombyx mori) microRNAs and their expressions in multiple developmental stages. PLoS One 2008, 3(8):e2997. 73.　 Ye Z, Hu S, Yu J: Adaptive clustering algorithm for community detection in complex networks. Physical Review E, Statistical, Nonlinear, and Soft Matter Physics 2008, 78(4 Pt 2):046115. 74.　 Wang W, Meng B, Ge X, Song S, Yang Y, Yu X, Wang L, Hu S, Liu S, Yu J: Proteomic profiling of rice embryos from a hybrid rice cultivar and its parental lines. Proteomics 2008, 8(22):4808-4821. 75.　 Wang W, Luo Q, Guo H, Bossier P, Van Stappen G, Sorgeloos P, Xin N, Sun Q, Hu S, J. Y: Phylogenetic analysis of brine shrimp (Artemia) in China using DNA barcoding. Genomics Proteomics Bioinformatics 2008, 6(3-4):155-162. 76.　 Wang F, Wang J, Jian H, Zhang B, Li S, Zeng X, Gao L, Bartlett DH, Yu J, Hu S et al: Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3. PLoS One 2008, 3(4):e1937. (并列通讯作者) 77.　 Luo Y, Xu X, Ding Z, Liu Z, Zhang B, Yan Z, Sun J, Hu S, Hu X: Complete genome of Phenylobacterium zucineum--a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562. BMC Genomics 2008, 9:386. (并列通讯作者) 78.　 Luo Q, Zhou Q, Yu X, Lin H, Hu S, Yu J: Genome-wide mapping of conserved microRNAs and identification of their host transcripts in Tribolium castaneum. Journal of Genetics & Genomics 2008, 35(6):349-355. 79.　 Li X, Tian F, Huang H, Tan L, Zhu Z, Hu S, Sun C: Construction of the physical map of the gpa7 locus reveals that a large segment was deleted during rice domestication. Plant Cell Reports 2008, 27(6):1087-1092. 80.　 Li X, Tan L, Huang H, Zhu Z, Li C, Hu S, Sun C: Construction of a bacterial artificial chromosome (BAC) library of common wild rice (Oryza rufipogon Griff.) for map-based cloning of genes selected during the domestication of rice. Biotechnology Letters 2008, 30(3):555-561. 81.　 Li J, Wang Y, Hu S, Zhou R, Yu X, Wang B, Guan L, Yang L, Zhang F, Faraone SV: The monoamine oxidase B gene exhibits significant association to ADHD. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 2008, 147(3):370-374. (并列通讯作者) 82.　 Jiang Y, Zhou Z, Qian Y, Wei Z, Yu Y, Hu S, Li L: Plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in China. The Journal of Antimicrobial Chemotherapy 2008, 61(5):1003-1006. 83.　 Huang J, Zhang L-x, Hu S-n, Yu J: Optimizing expression of LZ-8 protein and primary assaying of its immunomodulatory activity. Journal of Zhejiang University (Agric & Life Sci) 2008, 34(1):7-12. 84.　 Huang J, Jiang X, Zhang X, Chen W, Tian B, Shu Z, Hu S: Expressed sequence tag analysis of marine fungus Schizochytrium producing docosahexaenoic acid. Journal of Biotechnology 2008, 138(1-2):9-16. 85.　 Ge X, Chen W, Song S, Wang W, Hu S, Yu J: Transcriptomic profiling of mature embryo from an elite super-hybrid rice LYP9 and its parental lines. BMC Plant Biology 2008, 8:114. (并列通讯作者) 86.　 Gao WR, Wang XS, Liu QY, Peng H, Chen C, Li JG, Zhang JS, Hu SN, Ma H: Comparative analysis of ESTs in response to drought stress in chickpea (C. arietinum L.). Biochemical and Biophysical Research Communications 2008, 376(3):578-583. (并列通讯作者) 87.　 Feng Y, Chen CJ, Su LH, Hu S, Yu J, Chiu CH: Evolution and pathogenesis of Staphylococcus aureus: lessons learned from genotyping and comparative genomics. FEMS Microbiology Reviews 2008, 32(1):23-37. 88.　 Chu C, Feng Y, Chien AC, Hu S, Chu CH, Chiu CH: Evolution of genes on the Salmonella virulence plasmid phylogeny revealed from sequencing of the virulence plasmids of S. enterica serotype Dublin and comparative analysis. Genomics 2008, 92(5):339-343. 89.　 Chen S-L, Sun Y-Q, Song J-Y, Li Y, Li C-J, Hu S-N, Li X-W, Yao H, Zhang X-W: Analysis of expressed sequence tags (EST) from Panax quinquefolium root. Acta Pharmaceutica Sinica 2008, 43(6):2-8. 90.　 Chen K, Meng Q, Ma L, Liu Q, Tang P, Chiu C, Hu S, Yu J: A novel DNA sequence periodicity decodes nucleosome positioning. Nucleic Acids Research 2008, 36(19):6228-6236. 91.　 Chen H, Xu G, Zhao Y, Tian B, Lu H, Yu X, Xu Z, Ying N, Hu S, Hua Y: A novel OxyR sensor and regulator of hydrogen peroxide stress with one cysteine residue in Deinococcus radiodurans. PLoS One 2008, 3(2):e1602. (并列通讯作者) 92.　 Zhou X, Wang W, Lu F, Hu S, Jiang L, Yan D, Zhang X, Yu X, Yu J, Qu J: A comparative gene expression profile of the whole eye from human, mouse, and guinea pig. Molecular Vision 2007, 13:2214-2221. 93.　 Zhang Z, Deng Y, Tan J, Hu S, Yu J, Xue Q: A genome-wide microsatellite polymorphism database for the indica and japonica rice. DNA Research 2007, 14(1):37-45. 94.　 Yan J, Tang H, Liu Y, Ma W, Zhang Q, Gao J, Jiao Z, Shang L, Jing Y, Hu S et al: Allele frequencies of mitochondrial D-loop (CA)n repeat polymorphism in six Chinese ethnic groups. Legal Medicine (Tokyo) 2007, 9(6):330-331. 95.　 Tian X, Zheng J, Hu S, Yu J: The discriminatory transfer routes of tRNA genes among organellar and nuclear genomes in flowering plants: a genome-wide investigation of indica rice. Journal of Molecular Evolution 2007, 64(3):299-307. 96.　 Song S, Qu H, Chen C, Hu S, Yu J: Differential gene expression in an elite hybrid rice cultivar (Oryza sativa, L) and its parental lines based on SAGE data. BMC Plant Biology 2007, 7:49. 97.　 Liu QY, Wang XX, Zhang JZ, Chen WH, He XW, Lin Y, Wang JF, Zhu Y, Hu SN, Wang XN: Mapping cynomolgus monkey MHC class I district on chromosome 6p13 using pooled cDNAs. Biotechnic & Histochemistry 2007, 82(4):267-272. 98.　 Gorodkin J, Cirera S, Hedegaard J, Gilchrist MJ, Panitz F, Jorgensen C, Scheibye-Knudsen K, Arvin T, Lumholdt S, Sawera M, Hu S et al: Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags. Genome Biology 2007, 8(4):R45. 99.　 Fan X, Fang Y, Hu S, Wang G: Generation and analysis of 5318 expressed sequence tags (ESTs) from filamentous sporophyte of Porphyra haitanensis Ueda (Rhodophyta). Journal of Phycology 2007, 43(6):1287 -1294. (并列通讯作者) 100.Cui P, Ji R, Ding F, Qi D, Gao H, Meng H, Yu J, Hu S, Zhang H: A complete mitochondrial genome sequence of the wild two-humped camel (Camelus bactrianus ferus): an evolutionary history of camelidae. BMC Genomics 2007, 8:241. (并列通讯作者) 101.Chen WH, Lv G, Lv C, Zeng C, Hu S: Systematic analysis of alternative first exons in plant genomes. BMC Plant Biology 2007, 7:55. 102.Chen H, Xu Z, Tian B, Chen W, Hu S, Hua Y: Transcriptional profile in response to ionizing radiation at low dose in Deinococcus radiodurans. Progress in Natural Science 2007, 17(5):529-536. (并列通讯作者) 103.Zhao H, Li Q, Li J, Zeng C, Hu S, Yu J: The study of neighboring nucleotide composition and transition/transversion bias. Science in China: Series C Life Sciences 2006, 49(4):395-402. 104.Zhang B, Liu Q, Yin W, Zhang X, Huang Y, Luo Y, Qiu P, Su X, Yu J, Hu S et al: Transcriptome analysis of Deinagkistrodon acutus venomous gland focusing on cellular structure and functional aspects using expressed sequence tags. BMC Genomics 2006, 7:152. 105. Yu H, Wang J, Ye J, Tang P, Chu C, Hu S, Chiu CH: Complete nucleotide sequence of pSCV50, the virulence plasmid of Salmonella enterica serovar Choleraesuis SC-B67. Plasmid 2006, 55(2):145-151. 106.Yang G, Deng Y-J, Yan C-X, Wu D-Y, Hu S-N, Zhu B-F, Li S-B, Zhang X-Q, Liu Y: Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese. Acta Academiae Medicinae Sinicae 2006, 28(2):240-243. 107.Yang G, Deng YJ, Hu S, Wu DY, Li SB, Zhu J, Zhu BF, Liu Y: HLA-A, -B, and-DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China. Tissue Antigens 2006, 67(2):146-152. 108.Yan J, Liu Y, Tang H, Zhang Q, Huo Z, Hu S, Jun Y: Mutations at 17 STR loci in Chinese population. Forensic Science International 2006, 162(1-3):53-54. 109.Tian X, Zheng J, Hu S, Yu J: The rice mitochondrial genomes and their variations. Plant Physiology 2006, 140(2):401-410. 1 1 0. S u Z, Dong X, Zhang B, Zeng Y, Fu Y, Yu J, Hu S: Gene expression profiling in porcine mammary gland during lactation and identification of breed- and developmental-stage-specific genes. Science in China: Series C Life Sciences 2006, 49(1):26-36. (并列通讯作者) 111.Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Hu S et al: The DNA sequence, annotation and analysis of human chromosome 3. Nature 2006, 440(7088):1194-1198. 112.Liu Q, Zhang X, Yin W, Li C, Huang Y, Qiu P, Su X, Hu S, Yan G: A catalog for transcripts in the venom gland of the Agkistrodon acutus: identification of the toxins potentially involved in coagulopathy. Biochemical and Biophysical Research Communications 2006, 341(2):522-531. 113.Liu Q, Hu S, Yin W, Su X, Zhang X, Li C, Qiu P, Yan G: Construction of a cDNA library from Agkistrodon acutus venom gland and identification of Agkihagin, a novel transcript for metalloproteinase. Chinese Journal of Pharmacology and Toxicology 2006, 20(2):81-90. 114.Deng Y, Yang G, Wu D, Hu S, Li S, Zhu J, Zhu B, Liu Y: HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing. Chinese Journal of Medical Genetics 2006, 23(1):103-106. Chen WH, Wang XX, Lin W, He XW, Wu ZQ, Lin Y, Hu SN, Wang XN: Analysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our understanding of its immune system. BMC Genomics 2006, 7:-. (并列通讯作者) 北京基因组研究所“传承者读书会”——《基因组那点事与我的成长》 6月6日下午，基因组所一层报告厅内座无虚席，新一期“传承者”读书会在大家的期待中精彩开讲。本期主讲人胡松年研究员，以《基因组那点事与我的成长》为题，以通俗易懂的方式向大家介绍了什么是基因组学、基因组学的研究对象与技术发展，并讲述了自己在基因组科学领域中的探索和成长历程。 胡松年研究员投身基因组学研究已逾十五年，作为人类基因组计划1%部分和水稻基因组计划等在中国基因组学领域具有里程碑意义的重要事件的主要参与者和见证者，他在本学科领域内有很高的造诣和许多不为人知的深刻感悟。读书会上，他以幽默风趣的语言，为大家普及了基因组学的基础知识，让我们对世界基因组学突飞猛进的发展有了宏观的了解，对最新的仪器设备和技术方法有了进一步认识，报告中更令人印象深刻的是我国科研工作者排除万难、勇于探索的精神。 此次读书会，胡松年研究员的讲解让大家从另一个角度感受到了科学家的青春之路及与科学结下的不解之缘。讲至曾经在艰苦环境下科研人员不畏艰难克服压力并且苦中作乐的经历，在场听众也随之一起数度哽咽，无不动容。 人类基因组草图公布十周年纪念会 在人类基因组草图绘制完成10年后的2010年6月26日，由中国科协科学技术普及部、中国遗传学会、中国科学院北京基因组研究所、中国科学院遗传与发育生物学研究所共同主办的“人类基因组草图公布十周年纪念会”在北京国家会议中心隆重举行。中国科协科学技术普及部部长杨文志，中国科学院生命科学与生物技术局副局长苏荣辉，中国老年基因会秘书长常金城，中国科学院北京基因组研究所党委书记杨卫平，中国科学院北京基因组研究所副所长于军等领导，以及来自基因研究领域专家、学者等300余人出席了纪念会。 “我觉得国际人类基因组计划1%项目做下来很大的感觉对国家的荣誉。到4月，我们一共做了500198个（序列），当时做完之后没有欢呼雀跃的感觉，就是想终于做完了，没有给国家丢脸。那时的工作条件非常艰苦，陈老师（中国科学院原遗传研究所所长陈受宜）在我们工作的小楼内放了一张纸，上面写着‘穷棒子精神永放光芒！’。感觉精神的激励要远远大于肉体上的承受能力。做科研是一定要有一些精神，这是我做完1%项目最大的感触。”虽然国际人类基因组计划1%基因组测序项目完成已10年，但中国科学院北京基因组研究所研究员胡松年回想当年时仍抑制不住激动之情，在发言中数度哽咽。

生平

幼孤贫，母粥机织，供他读书。松年读书过目不忘，尤其精通《易经》。政和二年（公元1112年）任潍州教授，八年，经徽宗面试，改校书郎兼资善堂赞读。为殿试参详官，以沈晦第一，徽宗十分高兴，说：“朕久闻晦名，今乃得之”。松年迁中书舍人，不久，除给事中、兼侍讲。高宗年间，先后自左朝奉大夫拜吏部尚书，迁端明殿学士，除签书枢密院事，权参知政事（副宰相）。又进礼部尚书、参知政事。胡松年积极抗金，并在军队建设、选用人才、对金斗争策略等重大问题上，都直言敢谏，提出了许多好的建议。后来，以疾提举洞霄宫，卜居阳羡言村（今宜兴宜城东约4里处）。他筑堂以自娱，匾日“横山”，由孙觌题书“横山堂”。并题诗云：“波间指点见青红，雪脊山曾棱倚半空。幻出生绡三四幅，游人浑在画图中。苍云千里荫平宽，露叶风枝绕舍寒。莫遣先生赋归去，且令小吏报平安。”松年虽闲居乡间，但仍不忘朝廷之事，对“和耀科敛、防秋利害”屡有进言，帝皆嘉纳。

他忧刚国忧民，为官清正。在出任平江（今苏州）知府时，人还未到任所，贪官污吏、土豪劣绅便闻风敛迹。他到任以后，在大街上张榜公布兴利除害等17件大事，让广大百姓献计献策，监督执行，深受人民拥护爱戴。他曾多次上书朝廷，建议坚决抗金，大造战船，建立水军，加强长江防线，得到朝廷的赏识。朝廷要派人出使金国，不少人人感到疑虑和害怕，胡松年挺身而出，接受朝廷出使金国的任命。在金国朝廷上，不顾个人安危，不辱使命，出色地维护了国家和民族的尊严。因主战有功，被提升为吏部尚书权参知政事。朝廷每次给予他的赏赐，都以“军兴费广”为由拒受。有人劝他积蓄点钱财，留给子孙，他都以“儿孙自有儿孙福”、“给子孙留财产，会助长子孙懒惰”的道理，婉言谢绝。他的高风亮节、优良品质，备受时人的尊敬和后代的赞誉。秦桧当政时．胡松年从不“曲意阿附”。宋绍兴五年，胡松年因遭攻讦而引疾辞职，改任宣州知州。绍兴十六年（1146年）胡松年病逝，享年60岁，墓葬宜城梅林，后迁葬故里。

历史评价

松年平生不喜蓄财，不立异沽名，喜宾客，薪俸收入常不够支用。有人以为子孙计，劝其节用，松年曰：“贤而多财则损其志，况俸禀，主上所以养老臣也。”又当时秦桧为相，士大夫出于自身安危考虑，多曲意阿附于他，只有松年鄙视秦桧，至死不与秦桧通一封书信。这些，都深得世人的高度赞誉。